颈部淋巴结核(infectious cervical lymphadenitis)CT病例图片影像诊断分析其他 2010-11-29
【临床病史】：患者，21岁女性出现双侧颈部包块，有触痛。21-year-old woman with tender, bilateral neck masses
【影像表现】：Figure 1 and Figure 2: Contrast-enhanced CT coronal reformatted images demonstrating bilateral, bulky cervical lymph nodes that are centrally hypodense, representing necrosis, with peripheral enhancement (red arrows). 图1和图2，冠状位增强CT重建像显示双侧、大团状颈部淋巴结，中央低密度代表坏死，伴有外周强化（红箭）
Figure 3, Figure 4, and Figure 5: Axial images showing the extensive volume of necrotic lymphadenopathy and medial displacement of major vascular structures (blue arrowheads in Figure 5). 轴位影像显示广泛的坏死性淋巴结肿大，伴有邻近大血管结构向内侧移位。
Figure 6: A sagittal reconstruction highlights the confluent nature of the necrotic lymph nodes.矢状位重建显示坏死的淋巴结融合成团。
【影像诊断】：Scrofula (infectious cervical lymphadenitis) caused by mycobacterium tuberculosis 颈部淋巴结核
- Lymph nodes with centrally diminished (non-fatty) density on CT are abnormal, reflecting either necrosis or tumor infiltration. In an adult they are considered neoplastic until proven otherwise. 淋巴结在CT上表现为中心性密度减低（非脂性）是不正常的，反应坏死或肿瘤侵犯，在成人常常被考虑为肿瘤性，除非被证实为其他。
- In adults, 95% of scrofula cases are caused by mycobacterium tuberculosis, while in children, 90% are caused by non-tuberculous mycobacterium, such as mycobacterium avium intracellulare (MAI). 成人95％的瘰疬性脓肿由结核分枝杆菌引起，而儿童，90％为非结核性的分枝杆菌所引起，如鸟胞内分枝杆菌（MAI）
- Tuberculous lymphadenitis may be unilateral or bilateral and is usually found in Level 2, 3, 4, and 5 nodes.结核性淋巴结炎克雅氏单侧或双侧。
【讨论】：Scrofula, or infectious cervical lymphadenitis, is a term predominantly applied to tuberculous and non-tuberculous mycobacterial infections (NTM) affecting the cervical lymph nodes. Humans are the only reservoir for M. tuberculosis. Other tuberculous bacilli that cause disease in humans are M. bovis, and M. africanum, which most often cause extrapulmonary disease. NTM are ubiquitous, and reside in the soil. They can be found in contaminated water, dairy products, eggs, dust, and even tap water. Approximately 95% of adult scrofula cases are caused by mycobacterium tuberculosis, while the remaining 5% are caused by NTM, such as M avium intracellulare, M scrofulaceum, M kansasii and M chelonei. In children, this statistic is reversed, with NTM responsible for up to 92% of scrofula cases.
成人95％的瘰疬性脓肿由结核分枝杆菌引起，5％为NTM所引起，如鸟胞内分枝杆菌（MAI），M scrofulaceum, M kansasii and M chelonei.在儿童，则恰恰相反，92％以上的瘰疬为NTM所引起
Scrofula produces lymph nodes that are discrete, firm, and typically nontender, in contrast with the lymphadenopathy associated with acute infection that is often tender. A firm mass of matted nodes may become apparent with disease progression, and if untreated, lymphadenopathy can become fluctuant with draining fistulas. Enlarging nodes may compress the esophagus causing dysphagia. The presence of systemic symptoms is variable and more likely in immunocompromised patients.
Scrofula presents with a variable imaging appearance depending upon the stage of the disease. Tuberculous lymphadenitis may be unilateral (90% in adults) or bilateral and is usually found in the internal jugular nodal chains (levels 2 - 4) and the spinal accessory chains (levels 5a and 5b). In the early infectious phase, non-necrotic nodes have homogeneous signal intensity and enhance homogeneously with contrast on both CT and MR. As the disease progresses and nodes become necrotic, CT images demonstrate characteristic central low density, representing necrosis, with a thick rim of enhancement. Peripheral contrast enhancement reflects hyperemia of the inflamed lymph node capsule or increased lymph node vascularity. On MR images, the necrotic center of the nodes will show intermediate signal intensity on T1-weighted images, low signal intensity on T2-weighted images, and will enhance with contrast. The surrounding granulation tissue, with its inflammatory hypervascularity and increased vascular permeability, will be markedly hyperintense on T2-weighted images. The nodes may become multiloculated and matted, simulating metastatic cervical disease both on imaging and clinically. Despite extensive necrosis, infiltration of adjacent fat planes is minimal, which may differentiate this process from other infections or malignant nodal disease. Chronic or post-treatment nodes are characterized by fibrous and calcific elements that are easily identified on CT. Calcification can also be seen in scrofula caused by NTM. On MR, treated nodes are homogeneously hypointense on both T1 and T2-weighted images, and do not enhance with contrast.
Cervical lymph nodes enlarge in response to neoplastic, inflammatory, and systemic disease. The broad differential diagnosis of enhancing cervical lymphadenopathy in an adult includes, but is not limited to, metastatic squamous cell carcinoma, metastatic papillary thyroid carcinoma, lymphoma, tuberculous and nontuberculous mycobacterial lymphadenitis, cat-scratch disease, Kaposi sarcoma, AIDS-related lymphadenopathy, acute septic infection, Kimura disease, Castleman disease, and Kikuchi disease. Fungal infections and viral infections, such as Epstein-Barr virus, herpes simplex virus, cytomegalovirus, and rubella also may present with bilateral diffuse lymphadenopathy.
Diagnosis usually requires fine needle aspiration (FNA) for histologic examination and culture. Once scrofula is diagnosed, it is important to determine the exact etiology, as tuberculous scrofula is treated medically and NTM infections are treated surgically. Lymphadenopathy may initially worsen during antituberculous therapy, representing an immune response to killed mycobacteria. Surgical intervention is reserved for complications such as abscess formation and draining sinuses. The treatment of choice for NTM infections is complete surgical excision of all affected tissue.